肿瘤坏死因子在帕金森病中的研究进展

奕贤 刘; 迪娜·江阿旦; 佳欣 高; 诗惠 张; 亚琦 孟; 琳 许

doi:10.70693/cjmsr.v1i2.1254

Authors

奕贤刘大庆师范学院
迪娜·江阿旦大庆师范学院
佳欣高大庆师范学院
诗惠张大庆师范学院
亚琦孟大庆师范学院
琳许大庆师范学院

DOI:

https://doi.org/10.70693/cjmsr.v1i2.1254

Keywords:

帕金森病；肿瘤坏死因子；神经炎症;肠道菌群

Abstract

近年来，帕金森病(Parkinson's disease, PD)的患病率不断攀升，给社会带来持续增加的经济负担。PD确切的致病因素及发病机制仍不清晰，目前认为炎症反应与PD的发病机制及疾病发展过程密切相关。研究发现肿瘤坏死因子Tumor Necrosis Factor(TNF)是重要的炎症介质，并且研究表明TNF参与PD发病过程中的神经炎性反应，同时可介导神经元凋亡及功能的损害。本文通过归纳总结出TNF介导炎症反应在PD进展中的作用以及PD中TNF-α分子机制、信号通路及对脑-肠轴的影响，期望以此来为PD发病机制的研究提供参考。

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